York Regional Police said it happened at the intersection of 14th Avenue and Reesor Street just after 7 p.m.
A motorcycle and a van collided, resulting in the rider being taken to hospital with serious injuries.
Police said the motorcyclist was later pronounced dead. The driver of the van was not injured.
The cause of the collision is unknown.
Reesor Street is closed between Highway 7 and 14th Avenue for the investigation.
